How To Delete Files Which Windows Wont Delete?

so i have a few files that when i try to delete them it says this file may be in use by some other program and whatever and sometimes it just doesnt do anything. ive tried to get rid of them for a while using tuneup2007 but it doesnt work. anyone know how to get rid of them or a program that will?

If your'e sure they aren't used by another program, have you tried to delete them in safe mode

try this
http://www.softpedia.com/get/System/...Unlocker.shtml