mouse click inactive following reboot

I have a laptop and for some time after the start, the click of the mouse (both the left and right) no longer works. I can move the mouse without any problem but I can no longer click. After some time and a truly random clicks remarkable but it can take a day or two!
It is not a hardware problem because the problem is on both the mouse integrated mobile and additional mouse. However, the portable starting in Safe Mode, the problem is solved.
Could you help me?

Thanks in advance!

Hello,

Maybe reinstalling the drivers for your mouse!

I do not think it comes from the driver since the laptop mouse has the same problem

Hello,

Try a System Restore to a date prior to the problem.

Otherwise, Run sfc / scannow