Just to go back to the origin of this thread.
I have loaded the Freecom software that came with the Freecom 500GB external hard disk on 3 machines using Vista and in all instances it corrupted either the DVD or the USB ports. It was never clear whether the drivers were corrupted since the Vista Driver Manager reported the drivers as correct. The problem appeared to be that the operating system could not load them.
The only solution was to re-install the operating system from scratch and rebuild the systems.
Both MESH and Lenovo technical suspport resorted to this recovery option.
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