I am having a Vista system. I had bought the same a month ago. It has Vista pre-installed in the same. I am having a Optical Mouse 4000 wireless mouse. I was using the same on my XP desktop. Now to use on Vista I downloaded some fresh drivers from the offcial website. The mouse was detected. Some keys are not working. Like I cannot zoom in or simply cannot make changes to current configuration. I tried certain settings in Control Panel but there is no issue.