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I have resolved this....I quite simply did not have some Windows components installed! Thanks though :-)

Hi,
HKUS\S-1-5-18\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'SYSTEM')
Is this legit? To the best of my knowledge Windows Defender noted and allowed this registry change (I believe...