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If you use external DNS servers in your domain, you won't be able to access the intranet sites, exchange servers etc..

You need to find out what folder is taking much of the space... Some time it could be log files and temp files which can be deleted safely..

First of all, to delete all the temp files you can use...

Hi.. Did you try advanced boot options in windows? Are you able to boot from Boot cds? I don't think that there is really a Virus in your BIOS...(not sure if it is possible, in the first place to...